'Major setback' for the touring side as Atkinson leaves the field suffering a hamstring problem.
The English seamer added to England's injury problems upon exiting the ground during Saturday's play of the fourth Ashes Test against Australia.
Atkinson felt a problem in his left hamstring post-delivery of the fourth over on Saturday.
The England team stated the 27-year-old had experienced "tightness" and required time on the sidelines in order to be assessed "in the coming hours".
The concluding match of the series in Sydney starts this coming Sunday.
England have been without fast bowlers one seamer to a knee injury and another paceman to a side strain during this series.
A replacement bowler was called up as cover for Wood.
Atkinson struggled during the first two matches, taking just a handful of scalps.
He was dropped of the third Test, only to be brought back for the fourth Test as Archer's replacement.
The county bowler improved at the MCG, taking two wickets during the host's first knock, before adding 28 with the bat among just a trio of teammates to get into double digits.
Post a single over late on the first day, he resumed the next day and removed Scott Boland Scott Boland caught behind.
Yet, towards the conclusion of the fifth over, he sent down a slower ball to Travis Head and immediately felt his left hamstring.
Atkinson returned to the side for the Boxing Day Test after being left out the Adelaide game.
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