Early efforts from Spinazzola and Amir Rrahmani earned a win for the visitors at the Stadio Olimpico in a fixture marred by three dismissals.
This result propels Napoli to within a single point of Italian league pace-setters AC Milan, who prevailed on Friday. Inter hold third place but can return to the summit with a victory in their later fixture.
Despite missing several injured players, the southern Italian side controlled the game with patient build-up play. The first goal arrived when Politano's delivery was volleyed home by the wing-back at the back post.
The lead was doubled in the 32nd minute as Rrahmani guided a header from a Politano free-kick into the net. They went close to a third goal shortly after when Elmas saw his effort crash against the woodwork.
The second half brought further worry for the visitors when a player was forced off. This incident triggered a brief altercation, leading to yellow cards for a Napoli defender and Lazio's Noslin—who subsequently received a second caution for a challenge.
"I must congratulate the lads, performing with such a high standard of quality and intensity while preventing Lazio have control is difficult," stated the triumphant head coach. "We played at a exceptional level of quality."
Tensions boiled over again near the end as players from both sides became involved in a fierce confrontation, requiring the coach to step in. The two players were dismissed for their part in the clash.
Over in La Liga, Sevilla endured a heavy loss at home to struggling the Granotas. Levante established a lead with a well-worked move before adding two further goals in the second half to seal a comprehensive win.
In other news, Los Blancos face major pressure when they welcome Real Betis, after their arch-rivals extended their advantage at the top. Later on other game, Atlético Madrid travel to face La Real.
Turning to Ligue 1, a historic Parisian clasico takes place as Paris FC face powerhouses Paris Saint-Germain. This match marks the first top-flight meeting between the neighbors in decades, bringing significant spice to the weekend's action.
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